- Samurai Warriors
- Scaler
- Scarface: The World is Yours
- Scrapland
- Seablade
- Second Sight
- Sega GT 2002
- Sega NHL 2K3
- Serious Sam
- Serious Sam 2
- Shadow Ops: Red Mercury
- Shadow the Hedgehog
- Shark Tale
- Shellshock: Nam '67
- Shenmue II
- Shrek 2
- Shrek Super Slam
- Silent Hill 2: Inner Fears
- Silent Hill 4: The Room
- Silent Scope Complete
- Slam Tennis
- Soldier of Fortune II – Double Helix
- Sonic Mega Collection Plus
- Spartan : Total Warrior
- Spawn : Armageddon
- Speed Kings
- Sphinx & The Cursed Mummy
- Spiderman 2
- Spy vs. Spy
- Spyro : A Hero’s Tail
- SSX 3
- Star Wars : Battlefront
- Star Wars : Battlefront 2
- Star Wars : Jedi Knight - Jedi Academy
- Star Wars : Jedi Star Fighter
- Star Wars : Knights of the Old Republic
- Star Wars : Republic Commando
- Star Wars : The Clone Wars
- Star Wars Episode 3 : Revenge of the Sith
- Star Wars Jedi Knight 2 : Jedi Outcast
- Star Wars Knights of the Old Republic 2 : The Sith Lords
- State of Emergency
- Steel Battalion (NTSC)
- Still Life
- Stolen
- Street Fighter II Anniversary Collection
- Stubbs the Zombie in Rebel without a Pulse
- Sudeki
- Super Monkey Ball Deluxe
- SVC Chaos : SNK Vs. Capcom
- SWAT : Global Swat Team
- SX Superstar
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